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KMID : 0370219690130010001
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Yakhak Hoeji
1969 Volume.13 No. 1 p.1 ~ p.15
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Studies on the Complex Compounds and their Analytical Methods of Barbiturates by means of alpha-picoline-copper(II)
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김수억/Kim SU
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Abstract
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A new method of qualitative and quantitative determination of barbiturates in the pharmaceuticals by means of alpha-picoline-copper (II) was studied. Barbiturates in the pharmaceuticals were dissolved in the mixed solvent of 33% alpha-picoline-Carbontetrachloride to yield Complex Compounds of barbiturates-copper (II)-alpha-picoline. Complex Compounds of barbiturates show uniformly maximum absorption at the wavelength of 540mmc and were to be identified at the concentration of 1 X 10-4 Mole, and also was to be quantitatively determined at the concentration of 1x10-3 Mole. By this method barbiturates in the pharmaceuticals could be determined in the presence of various compounds such as sulpyrine, isopropylantipyrine, antipyrine, phenacetin and etc. But Barbiturates could be also determined by this method after separation with aminopyrine, acetaminophen, acetylsalicylic acid and etc. by column chromatography. And barbiturates and acetylsalicylic acid could be also determined by simultaneous equation while their complex compounds show uniformly each maximum absorption at the Wavelength of 540mmc. and 620mmc. I.R. spectra of these complex compounds show identification of Barbiturates derivatives. The composition ratio of these complex compounds were : barbiturates : Cu : alpha-picoline = 2 : 1 : 2
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